منابع مشابه
Improving baculovirus recombination.
Recombinant baculoviruses have established themselves as a favoured technology for the high-level expression of recombinant proteins. The construction of recombinant viruses, however, is a time consuming step that restricts consideration of the technology for high throughput developments. Here we use a targeted gene knockout technology to inactivate an essential viral gene that lies adjacent to...
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Digital libraries have, in the main, adopted the traditional library notion of the metadata “record” as the basic unit of management and exchange. Although this simplifies the harvest and re-exposure of metadata, it limits the ability of metadata aggregators to improve the quality of metadata and to share specifics of those improvements with others. The National Science Digital Library (NSDL) i...
متن کاملjpHMM: improving the reliability of recombination prediction in HIV-1
Previously, we developed jumping profile hidden Markov model (jpHMM), a new method to detect recombinations in HIV-1 genomes. The jpHMM predicts recombination breakpoints in a query sequence and assigns to each position of the sequence one of the major HIV-1 subtypes. Since incorrect subtype assignment or recombination prediction may lead to wrong conclusions in epidemiological or vaccine resea...
متن کاملImproving the recombination estimation method of Padhukasahasram et al 2006
The accuracy of the recombination estimation method of Padhukasahasram et al. 2006 can be improved by including additional informative summary statistics in the rejection scheme and by simulating datasets under a fixed segregating sites model. A C++ program that outputs these summary statistics is freely available from my website. We recently proposed a method for jointly estimating the populat...
متن کاملImproving Convergence of CMA-ES Through Structure-Driven Discrete Recombination
Evolutionary Strategies (ES) are a class of continuous optimization algorithms that have proven to perform very well on hard optimization problems. Whereas in earlier literature, both intermediate and discrete recombination operators were used, we now see that most ES, e.g. CMA-ES, use only intermediate recombination. While CMA-ES is considered state-of-the-art in continuous optimization, we be...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2003
ISSN: 1362-4962
DOI: 10.1093/nar/gng006